Lower-fat diet key to women’s liver health following weight-loss surgery

Research suggests that ladies who’ve weight reduction surgical procedure want to scale back the quantity of fats they eat after surgical procedure to reap the total good thing about the process and shield their liver operate. The examine is printed forward of print within the American Journal of Physiology-Endocrinology and Metabolism.

More than 42% of adults residing within the U.S. are thought of overweight and have the next threat of growing power well being circumstances equivalent to kind 2 diabetes, heart disease or most cancers. According to the American Society for Metabolic and Bariatric Surgery, an estimated 256,000 individuals within the U.S. had weight loss (bariatric) surgical procedure in 2019. As many as 80% of those circumstances are girls. Benefits of bariatric surgery—along with weight reduction—embody improved glucose tolerance and cholesterol levels, and higher coronary heart well being general. However, research have discovered that women and men don’t reply the identical strategy to weight reduction interventions. “There are indications that [biological] intercourse impacts the diploma of weight reduction and enhancements in comorbidities,” the researchers of a brand new examine in mice wrote.

The researchers studied a mouse mannequin of vertical sleeve gastrectomy, a type of weight loss surgery through which the abdomen is decreased to about 15% of its authentic measurement. After the process, a number of the mice remained on the high-fat weight loss program they have been fed earlier than surgical procedure, whereas others have been positioned on a lower-calorie weight loss program. The analysis workforce discovered each female and male mice had higher glucose tolerance and misplaced weight and physique fats after surgical procedure, even when they stayed on the high-fat weight loss program. However, the males had a bigger lower in liver fats storage (hepatic triglycerides) than the females. The male mice noticed enhancements in hepatic triglycerides no matter their weight loss program, whereas solely the females following a lower-calorie weight loss program confirmed vital enchancment. High ranges of hepatic triglycerides are a marker of fatty liver illness, which impacts as much as 100 million individuals within the U.S., in accordance with the Fatty Liver Foundation. Fatty liver illness can result in liver most cancers and liver failure in some circumstances.

“These information counsel that sustaining females on a [high-fat diet] diminishes the influence of surgical procedure on lowering hepatic triglycerides,” the researchers wrote. The findings “spotlight the significance of contemplating the additive influence of dietary intervention on surgical final result” in gentle of the intercourse variations related to weight reduction surgical procedure, defined Darleen Sandoval, Ph.D., of the University of Colorado-Anschutz Medical Campus, and corresponding creator of the examine.

“Diet-dependent intercourse variations within the response to vertical sleeve gastrectomy” is printed forward of print within the American Journal of Physiology-Endocrinology and Metabolism.