Healthy gut microbiome starts with the ‘right nutrition,’ bacterial diversity

Healthy gut microbiome starts with the ‘right nutrition,’ bacterial diversity

December 16, 2022

3 min learn


Healio Interviews

Hazan studies serving because the CEO of Venture Clinical Trials and has stake in Belia Therapeutics.

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Low bacterial variety and Bifidobacterium depletion have been related to severely symptomatic COVID-19 an infection in a small subset of sufferers — a sample of dysbiosis which will function a susceptibility marker for symptomatic severity.

“To struggle a virus one wants sturdy micro organism,” Sabine Hazan, MD, founder and CEO of analysis genetic sequencing laboratory ProgenaBiome in California, informed Healio. “After analyzing 1000’s of stool samples, I noticed markers of diseases in the microbiome.”

Sabine Hazan quote

In a cross-sectional research, Hazan and colleagues in contrast gut microbiome diversity and composition in sufferers with confirmed SARS-CoV-2 an infection, who ranged from asymptomatic to severely symptomatic, vs. a bunch of controls, who have been uncovered to SARS-CoV-2 however examined destructive and remained asymptomatic.

Compared with management people (n = 20), members with severely symptomatic COVID-19 an infection (n = 28) had much less bacterial variety, with decrease relative abundance of Bifidobacterium, Faecalibacterium and Roseburium. These sufferers did, nevertheless, have an elevated abundance of Bacteroides.

Sabine Hazan

“Our knowledge counsel a brand new space for exploration: If SARS-CoV-2 severity is discovered to be depending on the microbiome, then accounting for microbiome variations might scale back variability in outcomes for SARS-CoV-2,” Hazan and colleagues wrote in BMJ Open Gastroenterology.

To additional discover the implications of those outcomes, Hazan spoke with Healio about threat elements for an “unbalanced intestine,” finest protect the intestine microbiome and the necessity for added analysis.

Healio: What is the intestine microbiome and what function does it play in our susceptibility to sickness?

Hazan: It is actually trillions of micro organism, viruses, fungi and parasites all residing collectively.

They are essential to our immunity, our digestion, absorption of vitamins — they’re essential for all times, for my part.

Healio: Does the presence or lack of Bifidobacterium decide whether or not somebody has an unbalanced intestine?

Hazan: Absolutely, and the extra extreme circumstances are those who haven’t any Bifidobacterium —individuals who have most cancers, are overweight, have autoimmune ailments, power Clostridioides difficile an infection. Some neurological sufferers haven’t any Bifidobacterium. Also older adults, as a result of the method of getting old contains lack of Bifidobacterium — you’re born with plenty of Bifidobacterium and also you die with none.

Bifidobacterium is an important group of micro organism which are wanted for immunity, for my part. We are additionally seeing this in analysis to date.

Healio: How would somebody know whether or not their intestine is unbalanced?

Hazan: What we Ire now creating at ProgenaBiome is an assay that can determine these high-risk markers. It is just obtainable below analysis protocol proper now. The microbiome may be very complicated and if you begin telling sufferers they’ve sure micro organism which are excessive or low, it’s important to clarify it to them. Further validation and knowledge are wanted.

Healio: What can individuals do to appropriate an imbalance of micro organism within the intestine?

Hazan: It may be very troublesome to appropriate Bifidobacterium after getting misplaced it. If you’ve got none, that you must start taking good probiotics. Unfortunately, the issue with probiotics is they aren’t regulated. In different phrases, that you must ask whether or not it’s a stay micro organism probiotic or a lifeless probiotic.

Vitamins are additionally essential: Vitamins C and D enhance your microbiome and, once more, the standard of the vitamin is essential.

Then, after all, there may be avoiding destruction. For instance, drinking a glass of wine helps your Bifidobacterium, however 4 glasses of wine don’t. If you’re consuming meals that include antibiotics, like some meat, that doesn’t assist your Bifidobacterium. You should be very sensitive with antibiotics relating to whether or not you really want it, as a result of although it might deal with that dangerous bacterium, an excessive amount of has the potential to kill your Bifidobacterium.

Healio: What recommendation would you give individuals who need to protect their intestine microbiome?

Hazan: Diet is essential and educating yourself on food is essential. There are many meals individuals ought to begin consuming to enhance their intestine and the manufacturing facility that’s your colon. We are alleged to be making Bifidobacterium and it begins with the best diet.

Physicians ought to advise their sufferers to deal with diet and enhance their fermented meals consumption.

Healio: What further analysis is required on this space?

Hazan: There is plenty of analysis wanted. Research is required to find out which meals enhance the microbiome and which kill Bifidobacterium. The identical analysis is required for drugs, in addition to investigating how lengthy it takes Bifidobacterium to develop again.

It is troublesome as a result of plenty of this analysis is controversial — it’s new knowledge and the analysis may be very costly. We depend on docs for his or her assist in being part of the analysis. I really feel the microbiome depends on a patient-doctor relationship.


For extra data and analysis on the intestine microbiome, go to



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