Eating a diet very low in calories paves way for risky gut bacteria

Weight loss is usually a lengthy, typically irritating course of, doubtlessly driving some dieters to drastically cut back the variety of energy they eat in an effort to burn fats. While consuming a really low-calorie weight loss program will help cut back physique weight, a brand new examine has discovered that it could additionally pave the way in which for a dangerous pathogenic bacterium to take maintain within the intestine.

The new examine comes from scientists on the University of California – San Francisco, the place it was discovered that limiting one’s self to 800 energy a day can successfully assist individuals drop some weight, however with a doubtlessly undesirable impact on intestine micro organism. The examine concerned 80 post-menopausal ladies who had been placed on an 800-calorie liquid weight loss program for 16 weeks.

Fecal samples had been collected from the members earlier than and after the weight-reduction plan interval to find out the consequences a really low-calorie weight loss program might have on the intestine microbiome. The samples had been transplanted into mice that had been raised in a sterile surroundings, revealing one massive shock: the mice that acquired post-diet transplants misplaced weight.

When wanting into the micro organism profiles in an try to find out what could also be serving to drive the load loss, the researchers discovered increased than regular ranges of a pathogenic micro organism known as C. difficile. This can be because of the lower in secondary bile acids that ordinarily hold the C. difficile inhabitants underneath management.

Of observe, C. difficile can lead to extreme hard-to-treat intestinal illness — but it wasn’t linked to the presence of colitis or heightened irritation within the case of this examine, indicating that it could additionally play an vital position in metabolism.

However, the researchers warning that extra work is critical and that folks determined to drop some weight shouldn’t keep on with a particularly low-calorie weight loss program in an effort to shed kilos. The examine’s senior writer Peter Turnbaugh, Ph.D., explained, “Let’s be clear; we’re undoubtedly not selling C. difficile as a brand new weight reduction technique. We’ve bought quite a lot of biology left to unpack right here.”

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