Weight loss via diet or gastric bypass yield similar metabolic benefits


Eagon C, Presented at: Digestive Disease week; May 21-23, 2021 (digital assembly).

Eagon reviews no related monetary disclosures. Please see the research for all different authors’ related monetary disclosures.

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Insulin sensitivity and beta cell perform improved amongst sufferers with kind 2 diabetes after 18% physique weight loss by diet or gastric bypass, in response to a research offered at Digestive Disease Week.

“Significant weight reduction, whether or not secondary to medical remedy or surgical remedy, has profound advantages in lowering diabetes. Bariatric surgery has constantly been proven to have a higher impression on kind 2 diabetes,” Christopher Eagon, MD, Washington University School of Medicine, stated. “In randomized and nonrandomized research inside various kinds of bariatric surgical procedure, there are variations within the charge of diabetes remission variations after the surgical procedure. … Among kind 2 diabetes sufferers, the extent to which the insulin axis of metabolic perform could also be affected by weight reduction dependent vs. weight reduction unbiased components is unclear.”

In a non-randomized, matched cohort research, researchers analyzed sufferers with kind 2 diabetes to measure metabolic modifications after important weight reduction by weight-reduction plan vs. gastric bypass. Of 33 sufferers, 15 sufferers underwent gastric bypass and 18 underwent weight-reduction plan modifications; they additional underwent baseline measurements earlier than and after 18% physique weight reduction.

According to check outcomes, weight reduction within the weight-reduction plan group and the gastric bypass group correlated with elevated insulin-stimulated glucose disposal (30.5-61.6 µmol/kg of fat-free mass vs. 29.4-54.5 µmol/kg of fat-free mass, respectively). Weight loss additionally correlated with elevated beta cell perform by 1.83 items (95% CI, 1.22-2.44) within the weight-reduction plan group and by 1.11 items (95% CI, 0.08-2.15) within the gastric bypass group. Researchers additional famous decreases in areas underneath the curve for 24-hour plasma glucose and insulin ranges.

“After 18% weight reduction by weight-reduction plan or gastric bypass, built-in glucose and insulin throughout fasting/fed states are the identical, beta cell responsiveness is similar, tissue-specific inside physique insulin sensitivity is similar and beta cell perform is similar,” Eagon concluded. “When it involves total insulin sensitivity and beta cell perform, it seems that weight reduction can account for all the development in these parameters.”

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