Researchers reveal how to effectively achieve and maintain a healthy weight loss

Almost one in 5 Danes dwell with weight problems, which can have severe well being penalties. In the world’s most acknowledged medical journal, Danish researchers now doc the way to successfully obtain and keep a wholesome weight reduction.

Half of the Danish inhabitants have chubby, whereas 17 % dwell with weight problems. Worldwide, virtually 40 procent have chubby and 13 procent dwell with weight problems.

The situation is related to elevated threat for early dying, in addition to sequelae similar to Type 2 diabetes, cardiovascular ailments, most cancers, and infertility.

Weight regain after an preliminary profitable weight reduction in folks with weight problems, constitutes an vital and unsolved downside. Until now, no well-documented research on which remedy methodology is finest for sustaining a wholesome weight reduction has been accessible.

Researchers at University of Copenhagen and Hvidovre Hospital have accomplished a brand new, sensational research, which is being printed on this planet’s most quoted medical journal, The New England Journal of Medicine. By testing 4 several types of remedy following a diet-induced weight reduction, the researchers exhibit for the primary time how it’s potential for folks with weight problems to keep up long-term weight reduction, says Professor Signe Torekov on the Department of Biomedical Sciences.

In a randomized scientific trial, the group of researchers has demonstrated a extremely efficient remedy after a diet-induced weight reduction, by combining reasonable to vigorous-intensive train with appetite-inhibiting weight problems treatment, an analogue to the appetite-inhibiting hormone GLP-1.

“This is new data for docs, dietitians and bodily therapists to make use of in apply. This is proof that we now have been lacking,” explains Signe Torekov, who has been heading the research.

“The downside is that individuals are preventing towards sturdy organic forces when losing a few pounds. The urge for food will increase concurrently with decreased power consumption, and this counteracts weight reduction upkeep. We have an appetite-stimulating hormone, which will increase dramatically after we drop some pounds, and concurrently the extent of appetite-suppressing hormones drops dramatically. In addition, a weight reduction can provoke lack of muscle mass, whereas the physique reduces the power consumption. Thus, when the main focus in weight problems remedy has been on the way to acquire a weight reduction – reasonably than the way to keep a weight reduction – it’s actually tough to do one thing about your scenario,” says Signe Torekov.

Highly environment friendly when combining remedies

215 Danes with weight problems and low health scores participated within the research. The members initially adopted a low calorie eating regimen over eight weeks, the place they every misplaced roughly 13 kg, which introduced important enhancements to their well being with a drop in blood sugar stage and blood stress.

The members have been then randomly divided into 4 teams. Two of the teams acquired placebo treatment, whereas the 2 different teams acquired weight problems treatment. Among the 2 placebo teams, one group adopted an train program of minimal 150 minutes of bodily exercise at reasonable depth or 75 minutes at vigorous-intensity throughout the week or a mixture of the 2, whereas the opposite group maintained their present stage of bodily exercise. The two teams receiving weight problems treatment have been equally divided into one group with and one group with out an train program.

All members within the research have been weighed month-to-month and acquired dietary and eating regimen counseling with the concentrate on wholesome weight reduction in accordance with the rules from the Danish well being and meals administrations.

After one 12 months, the group with train alone and the group with weight problems treatment alone maintained the burden lack of 13 kg and well being enhancements. The placebo group gained half of the burden again with deterioration of all threat components, for instance for development of Type 2 diabetes and heart problems.

The most dramatic enhancements occurred within the mixture group, which adopted the train program and acquired weight problems treatment. The researchers noticed further weight reduction on this group, and the whole weight reduction was roughly 16 kg over one 12 months. The well being advantages have been additionally double that of every of the one remedies, i.e., twice the lack of fats mass whereas preserving muscle mass, larger health scores, lowered blood sugar and improved high quality of life.

The two teams that exercised elevated their health score, misplaced fats mass, and gained muscle mass. This might point out a more healthy weight reduction than for folks, who had solely misplaced fats mass with out growing the health score.

It is a vital side to focus on, as you don’t essentially get a more healthy physique from losing a few pounds if, on the identical time, you lose loads of muscle mass.”

Professor Signe Torekov, Department of Biomedical Sciences, University of Copenhagen

“It is nice information for public well being {that a} important weight reduction will be maintained with train for roughly 115 minute per week carried out principally at vigorous-intensity, similar to biking. And that by combining train with weight problems treatment, the impact is twice nearly as good as every of the person remedies”.”

With the research, the researchers now hope folks with weight problems, along with their care supplier, can create a helpful framework for sustaining the burden loss.

Fundamental way of life change

Signe Torekov factors out that many individuals with weight problems have tried to drop some pounds earlier than, solely to regain the burden. This occurs, as a result of the final recommendation is to eat more healthy and train extra.

“Without a follow-up on whether or not folks even have help to carry out train, the remedy won’t be sufficient. Therefore, we additionally adopted up with the members on an ongoing foundation to make sure that they acquired the help they wanted as a way to train. That is important, as a result of sustaining weight reduction is extraordinarily arduous. People want to know this. Once you will have misplaced weight, you aren’t “cured”. “The ongoing train and energy will seemingly must proceed for a few years,” says Signe Torekov.

“Our research additionally demonstrates that with no structured remedy plan, there’s a excessive threat of gaining the burden again. There have been 12 particular person consultations over the course of a 12 months, together with weighing and eating regimen recommendation from Danish authorities in accordance with pointers for wholesome weight upkeep. This was simply not sufficient for the placebo group with out train program, on this group all well being advantages gained by weight reduction throughout the eight week program have been gone after one 12 months, regardless of frequent weighing and eating regimen and dietary counseling based mostly on official pointers”. Torekov says.

According to Signe Torekov, this underscores the significance of taking part in a mutual weight upkeep program based mostly on suggestions when beginning a weight reduction programme.

“Therefore, it is crucial that there’s a system for supporting folks with weight problems in sustaining the life-style change. Our research will help with this, as a result of we are able to say this really works to docs, dietitians and municipalities, in the event that they create a structured, joint remedy plan with the person utilizing ongoing follow-ups,” says Torekov.


Journal reference:

Lundgren, J.R., et al. (2021) Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined. New England Journal of Medicine.

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