Novo Nordisk’s weight loss drug semaglutide found to improve wellbeing

Novo Nordisk’s weight loss drug semaglutide found to improve wellbeing
Novo Nordisk’s weight loss drug semaglutide found to improve wellbeing

New outcomes from a Phase IIIa examine have demonstrated that Novo Nordisk’s weight reduction drug semaglutide improved bodily operate and wellbeing amongst folks with weight problems.

The STEP 1 trial demonstrated advantages for folks with weight problems handled with semaglutide 2.4mg ‘past weight reduction’, Novo mentioned in an announcement.

Over a 68-week interval, remedy with once-weekly semaglutide 2.4mg was related to higher enhancements for all weight- and health-related high quality of life scores in folks with weight problems or obese compared to placebo.

This included improved wellbeing, with 43.8% of sufferers handled with Novo’s drug attaining a clinically significant enchancment in whole weight-related high quality of life rating at week 68.

On prime of that, 51.2% of individuals handled with semaglutide 2.4mg within the trial had an elevated weight-related bodily operate rating, reflecting enhancements within the means to carry out each day actions.

In addition, sufferers handled with semaglutide 2.4mg ‘concurrently’ skilled important weight lack of 14.9% over greater than a 12 months.

The security profile for semaglutide 2.4mg is ‘in line’ with earlier observations seen with glucagon-like peptide-1 (GLP-1) receptor agonists, with the commonest hostile occasions being gastrointestinal occasions.

“I’m actually pleased with these outcomes. Obesity shouldn’t be solely concerning the weight itself; residing with this power illness impacts all features of an individual’s life akin to not with the ability to climb stairs or transfer round as a part of one’s each day routines,” mentioned Martin Holst Lange, government vp, growth at Novo Nordisk.

“This has implications each for bodily and psychological well being. This examine reveals that remedy with semaglutide 2.4 mg improves psychological and bodily wellbeing. It holds actual potential to enhance the lives of individuals residing with weight problems,” he added.

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